Alam Z, Coombes N, Waring R H, Williams A C, Steventon G B
School of Biochemistry, University of Birmingham, Edgbaston, UK.
Cephalalgia. 1997 Nov;17(7):761-4. doi: 10.1046/j.1468-2982.1997.1707761.x.
Activity of both the M- and P-forms of sulphotransferase (ST) was measured in platelets from patients with migraine, tension headache and controls. Mean PST values were 0.065 +/- 0.023 and 0.057 +/- 0.052 nmol/mg protein/min for migraine patients with and without aura. The corresponding values for tension headache and controls were 0.122 +/- 0.059 and 0.127 +/- 0.093 nmol/mg protein/min respectively (p < 0.05). Mean MST values were not different for any of the groups, and MST and PST activities measured in two patients during a migraine attack were not significantly altered from baseline levels. Mean plasma inorganic sulphate concentrations and paracetamol metabolites were not significantly different in any of the groups studied. The results suggest that PST activity may be a factor in the aetiology of migraine.
在偏头痛患者、紧张性头痛患者及对照组的血小板中，测定了磺基转移酶（ST）的M型和P型的活性。有先兆和无先兆偏头痛患者的PST平均活性值分别为0.065±0.023和0.057±0.052 nmol/mg蛋白质/分钟。紧张性头痛患者及对照组的相应值分别为0.122±0.059和0.127±0.093 nmol/mg蛋白质/分钟（p<0.05）。各组的MST平均活性值无差异，且两名患者在偏头痛发作期间测得的MST和PST活性与基线水平相比无显著变化。在任何研究组中，血浆无机硫酸盐平均浓度和对乙酰氨基酚代谢物均无显著差异。结果表明，PST活性可能是偏头痛病因中的一个因素。
