Assarzadegan Farhad, Asadollahi Mostafa, Derakhshanfar Hojjat, Kashefizadeh Azam, Aryani Omid, Khorshidi Mona
Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Emergency Department, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Child Neurol. 2015 Summer;9(3):13-6.
Migraine is known as one of the most disabling types of headache. Among the variety of theories to explain mechanism of migraine, role of serum magnesium is of great importance. Serum magnesium, as a pathogenesis factor, was considerably lower in patients with migraine. We established this study to see if serum ionized magnesium, not its total serum level, was different in migraineurs from normal individuals.
MATERIALS & METHODS: In this case control study, all participants were recruited from Neurology Clinic of Imam Hossein Hospital, Tehran, Iran. Ninety-six people were entered in the study, 48 for each of case and control groups. The two groups were matched by age and sex. Migrainous patients were selected according to the criteria of International Headache Society. Various characteristics of headache were recorded based on patients' report. Controls had no history of migraine or any significant chronic headaches. Serum ionized magnesium level was measured in both of the case and control groups and the results were compared to each other. P value of <0.05 was considered as significant.
Case group consisted of 13 males, 35 females, and control group included 14 males, as well as 34 females. Mean age was 33.47± 10.32 yr for case and 30.45 ±7.12 yr for control group. Twenty-eight patients described the intensity of their headaches as moderate; 15 patients had severe and the 5 remainders had only mild headaches. Mean serum level of ionized Mg was 1.16± 0.08 in case group and 1.13± 0.11 in control group of no significant difference (P >0.05).
Serum ionized magnesium, which is the active form of this ion, was not significantly different in migraineurs and those without migraine. This may propose a revision regarding pathogenesis of migraine and question the role of magnesium in this type of headache.
偏头痛是最使人丧失能力的头痛类型之一。在众多解释偏头痛发病机制的理论中，血清镁的作用至关重要。作为一种发病因素，偏头痛患者的血清镁水平显著较低。我们开展本研究以观察偏头痛患者与正常个体相比，血清离子镁而非血清总镁水平是否存在差异。
在本病例对照研究中，所有参与者均来自伊朗德黑兰伊玛目侯赛因医院神经内科门诊。96人参与本研究，病例组和对照组各48人。两组在年龄和性别上相匹配。偏头痛患者根据国际头痛协会的标准选取。基于患者报告记录头痛的各种特征。对照组无偏头痛病史或任何严重慢性头痛病史。对病例组和对照组均测量血清离子镁水平，并将结果进行相互比较。P值<0.05被视为具有统计学意义。
病例组包括13名男性、35名女性，对照组包括14名男性和34名女性。病例组平均年龄为33.47±10.32岁，对照组为30.45±7.12岁。28名患者称其头痛强度为中度；15名患者为重度，其余5名仅有轻度头痛。病例组血清离子镁平均水平为1.16±0.08，对照组为1.13±0.11，差异无统计学意义（P>0.05）。
血清离子镁作为该离子的活性形式，在偏头痛患者和非偏头痛患者中无显著差异。这可能提示对偏头痛发病机制进行修正，并对镁在这类头痛中的作用提出质疑。
