Liu L, Li X, Hong W
Department of the vagince, Cancer Institute (Hospital) Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1996 Sep;18(5):385-7.
In this paper, 22 patients from 1973 through 1994 with primary malignant melanoma are retrospectively analyzed. Vaginal bleeding, discharge and a tumor mass were the chief complaints. The most common site of the tumor origin was the lower third of the anterior and postrior vaginal wall. The 5-year survival rate of 18 previously untreated patients was 11% (2/18). Of the 18 patients, 9 in stage I treated by surgery and postoperative chemothreoapy and/or radiotherapy survived for an average of 33 months. Two of the 9 patients receiving radical surgery survived for more than 5 years. None of the remaining 9 patients in stage II-IV treated with chemotherapy and/or radiotherapy survived longer than 2 years. The survival time differed significantly in patients with and without pelvic lymph node metastasis (7 versus 41 months) and in those with and without vascular tumor thrombi (13 versus 43 months). Mitotic index of tumor cells and lymphocytic infiltration were of no prognostic value.
本文回顾性分析了1973年至1994年间22例原发性恶性黑色素瘤患者。主要症状为阴道出血、分泌物增多及肿物。肿瘤最常见的起源部位是阴道前、后壁下1/3。18例未经治疗的患者5年生存率为11%（2/18）。18例患者中，9例Ⅰ期患者接受手术及术后化疗和/或放疗，平均生存33个月。9例接受根治性手术的患者中有2例生存超过5年。其余9例Ⅱ-Ⅳ期接受化疗和/或放疗的患者均未生存超过2年。有盆腔淋巴结转移和无盆腔淋巴结转移患者的生存时间差异显著（7个月对41个月），有血管内肿瘤血栓和无血管内肿瘤血栓患者的生存时间差异也显著（13个月对43个月）。肿瘤细胞的有丝分裂指数和淋巴细胞浸润无预后价值。
