Yang R, Yin X, Zhang X
Second Hospital, China Medical University, Shenyang.
Zhonghua Wai Ke Za Zhi. 1996 Mar;34(3):167-9.
47 patients were stained by using methylene blue in fiberoptic bronchoscopy. Of these, 35 had central lung cancer, and 12 bronchitis. 40 patients with central lung cancer were detected by general fibreoptic endoscopy. The results demonstrated that normal bronchial mucosa was not stained, 97.14% central malignant bronchial tumors stained, and 8.33% bronchitis stained. X2test showed the marked difference. Positive diagnosis was 97.06% in biopsy specimens stained, it was higher than 77.05% in the general investigated (P < 0.05). Using methylene blue in fiberoptic bronchoscopy would help diagnose central lung cancer, determine tumors limits, permit accurate biopsy. The stain was not related to the pathological classification, differentiation of cancer cells, and classification of clinical pathology (P > 0.05).
47例患者在纤维支气管镜检查中使用亚甲蓝染色。其中，35例患有中央型肺癌，12例患有支气管炎。40例中央型肺癌患者通过普通纤维内镜检查被检测出来。结果表明，正常支气管黏膜未被染色，97.14%的中央型恶性支气管肿瘤被染色，8.33%的支气管炎被染色。X²检验显示出显著差异。染色活检标本的阳性诊断率为97.06%，高于普通检查的77.05%（P<0.05）。在纤维支气管镜检查中使用亚甲蓝有助于诊断中央型肺癌，确定肿瘤边界，进行准确活检。染色与癌细胞的病理分类、分化及临床病理分类无关（P>0.05）。
