Connor B, Beilharz E J, Williams C, Synek B, Gluckman P D, Faull R L, Dragunow M
Department of Pharmacology, Faculty of Medicine and Health Science, University of Auckland, New Zealand.
Brain Res Mol Brain Res. 1997 Oct 3;49(1-2):283-90. doi: 10.1016/s0169-328x(97)00192-7.
IGF-I has been shown to enhance neuronal survival and inhibit apoptosis. IGF-I immunoreactivity was examined in the Alzheimer's disease and normal post-mortem human hippocampus and temporal cortex to determine whether IGF-I protein levels are altered in response to neurodegeneration. IGF-I immunoreactivity was induced in a subpopulation of GFAP-immunopositive astroglia in the Alzheimer's disease temporal cortex. These observations raise the possibility that IGF-I has a neuroprotective role in the Alzheimer's disease brain.
胰岛素样生长因子-I（IGF-I）已被证明可增强神经元存活并抑制细胞凋亡。对阿尔茨海默病患者及正常死后人体海马体和颞叶皮质中的IGF-I免疫反应性进行了检测，以确定IGF-I蛋白水平是否会因神经退行性变而发生改变。在阿尔茨海默病颞叶皮质中，GFAP免疫阳性星形胶质细胞亚群中诱导出了IGF-I免疫反应性。这些观察结果提示，IGF-I在阿尔茨海默病大脑中可能具有神经保护作用。
