Panter S S, McSwigan J D, Sheppard J R, Emory C R, Frey W H
Neurochem Res. 1985 Dec;10(12):1567-76. doi: 10.1007/BF00988599.
A major protein associated with Alzheimer's disease (AD) was detected by an electrophoretic study of temporal cortex obtained at autopsy from patients affected with AD, non-AD dementia, and normal controls matched for age and sex. A markedly increased amount of a 50,000 dalton molecular weight protein, which has been identified as glial fibrillary acidic protein (GFAP), was observed in the crude nuclear fraction of temporal cortex from AD patients. These electrophoretic data may reflect the presence of GFAP immunopositive astrocytic processes that have been shown by immunocytologic methods to infiltrate the neurofibrillary tangles that characterize AD.
通过对死于阿尔茨海默病（AD）、非AD痴呆症患者以及年龄和性别匹配的正常对照者的颞叶皮质进行尸检获得的电泳研究，检测到一种与AD相关的主要蛋白质。在AD患者颞叶皮质的粗核部分中，观察到一种分子量为50,000道尔顿的蛋白质（已鉴定为胶质纤维酸性蛋白（GFAP））的含量显著增加。这些电泳数据可能反映了GFAP免疫阳性星形细胞过程的存在，免疫细胞学法已表明这些过程会渗入作为AD特征的神经原纤维缠结中。
