丹参对脑缺血再灌注损伤中一氧化氮的影响。
Effect of radix Salviae miltiorrhizae on nitric oxide in cerebral ischemic-reperfusion injury.
作者信息
Kuang P, Tao Y, Tian Y
机构信息
Neurotransmitter Research Laboratory, Chinese PLA General Hospital, Postgraduate Medical School, Beijing.
出版信息
J Tradit Chin Med. 1996 Sep;16(3):224-7.
It has been postulated that nitric oxide (NO) is produced in significant amount on reperfusion of ischemic brain and could cause brain edema and cell death. This study was undertaken in an attempt to determine whether Radix Salviae Miltiorrhizae (RSM) could reduce cerebral NO contents in 4-vessel occlusion rat model after 30 min of global ischemia and 15 min of reperfusion. There was a significant increase in cerebral NO level in untreated animals as compared with sham-operated ones. By pretreatment with RSM the cerebral NO concentration was reduced to normal level. The possibilities of neuroprotective role of RSM in cerebral ischemic-reperfusion injury were discussed.
据推测，一氧化氮（NO）在缺血性脑再灌注时大量产生，可导致脑水肿和细胞死亡。本研究旨在确定丹参（RSM）是否能降低四血管闭塞大鼠模型在全脑缺血30分钟和再灌注15分钟后的脑NO含量。与假手术组相比，未治疗动物的脑NO水平显著升高。通过丹参预处理，脑NO浓度降至正常水平。讨论了丹参在脑缺血再灌注损伤中发挥神经保护作用的可能性。
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