Liu J, Kuang P, Wu W, Zhang F, Liu J, Wan F, Huang Y, Ding A
Neurotransmitter Research Laboratory, Chinese PLA General Hospital, Postgraduate Military Medical School, Beijing.
J Tradit Chin Med. 1998 Mar;18(1):49-54.
Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicinal herb, has been used to improve blood circulation and resolve blood stasis. We have previously found that RSM has neuroprotective effect on ischemia and/or ischemia-reperfusion rats. The purpose of this study was to obtain further information on the mechanism of the RSM-induced neuroprotection and to examine the neuroprotective effect on neurons exposed to anoxia. The effect of RSM on anoxic damage in cultured hippocampal neurons of neonatal rat was investigated by using morphological changes and heat shock protein 70 kD (HSP70) expression as indicators. RSM given 0.5 h before 2 h-anoxia followed by 48 hours reoxygenation could significantly increase survival rate of hippocampal neurons and number of HSP70 positive cells. The results suggest that RSM has a direct neuroprotective effects on anoxic damage in hippocampal neurons.
丹参，一种著名的传统中草药，一直被用于促进血液循环和活血化瘀。我们之前发现丹参对缺血和/或缺血再灌注大鼠具有神经保护作用。本研究的目的是进一步了解丹参诱导神经保护的机制，并研究其对缺氧神经元的神经保护作用。以形态学变化和热休克蛋白70 kD（HSP70）表达为指标，研究丹参对新生大鼠海马神经元缺氧损伤的影响。在缺氧2小时前0.5小时给予丹参，然后再进行48小时复氧，可显著提高海马神经元的存活率和HSP70阳性细胞数量。结果表明，丹参对海马神经元的缺氧损伤具有直接的神经保护作用。
