丹参对脑梗死的药理作用。
Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction.
机构信息
Department of Chinese Medicine, China Medical University Hospital, Taichung, 40402, Taiwan.
出版信息
Chin Med. 2010 Jun 21;5:22. doi: 10.1186/1749-8546-5-22.
Abstract
Danshen, the dried root of Salvia miltiorrhiza, is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects.
摘要
丹参，即唇形科植物丹参的干燥根，是一种中药，用于促进血液流动和治疗血管疾病。本文综述了丹参对脑梗死的药理作用及丹参与西药的相互作用。丹参可能减少或延长动脉粥样硬化的发展，具有降压和抗血小板聚集作用，从而预防脑梗死。丹参可能增强内源性抗氧化酶的活性，如内皮型一氧化氮合酶的表达，并能清除氧自由基。丹参预防和治疗脑梗死涉及多种途径，包括抗动脉粥样硬化、降压、抗血小板聚集、抗炎和抗氧化作用。
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