丹参对脑梗死的药理作用。
Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction.
机构信息
Department of Chinese Medicine, China Medical University Hospital, Taichung, 40402, Taiwan.
出版信息
Chin Med. 2010 Jun 21;5:22. doi: 10.1186/1749-8546-5-22.
Abstract
Danshen, the dried root of Salvia miltiorrhiza, is a Chinese medicine used to promote blood flow and treat vascular disease. The present article reviews the pharmacological effects of Danshen on cerebral infarction and possible interactions between Danshen and Western drugs. Danshen may reduce or prolong the development of atherosclerosis and may have anti-hypertensive and anti-platelet aggregation effects, which prevent cerebral infarction. Danshen may enhance endogenous anti-oxidative enzyme activities such as the expression of endothelial nitric oxide synthase and may scavenge oxygen free radicals. Prevention and treatment of cerebral infarction by Danshen involves multiple pathways, including anti-atherosclerosis, anti-hypertension, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects.
摘要
丹参，即唇形科植物丹参的干燥根，是一种中药，用于促进血液流动和治疗血管疾病。本文综述了丹参对脑梗死的药理作用及丹参与西药的相互作用。丹参可能减少或延长动脉粥样硬化的发展，具有降压和抗血小板聚集作用，从而预防脑梗死。丹参可能增强内源性抗氧化酶的活性，如内皮型一氧化氮合酶的表达，并能清除氧自由基。丹参预防和治疗脑梗死涉及多种途径，包括抗动脉粥样硬化、降压、抗血小板聚集、抗炎和抗氧化作用。
相似文献
1
Pharmacological effects of Salvia miltiorrhiza (Danshen) on cerebral infarction.
Chin Med. 2010 Jun 21;5:22. doi: 10.1186/1749-8546-5-22.
2
Salvia miltiorrhiza Bunge (Danshen) extract attenuates permanent cerebral ischemia through inhibiting platelet activation in rats.
J Ethnopharmacol. 2017 Jul 31;207:57-66. doi: 10.1016/j.jep.2017.06.023. Epub 2017 Jun 20.
3
Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial.
PLoS One. 2015 Jul 20;10(7):e0128695. doi: 10.1371/journal.pone.0128695. eCollection 2015.
4
Danshen (Salvia miltiorrhiza Bunge): A Prospective Healing Sage for Cardiovascular Diseases.
Curr Pharm Des. 2017;23(34):5125-5135. doi: 10.2174/1381612823666170822101112.
5
[Study on clinical characteristics of Danshen Chuanxiongqin Injection in treatment of cerebral infarction in real world].
Zhongguo Zhong Yao Za Zhi. 2020 Jul;45(14):3307-3315. doi: 10.19540/j.cnki.cjcmm.20200327.501.
6
Aqueous extract of danshen (Salvia miltiorrhiza Bunge) protects ovariectomized rats fed with high-fat diet from endothelial dysfunction.
Menopause. 2013 Jan;20(1):100-9. doi: 10.1097/gme.0b013e31825b512d.
7
In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase.
Phytomedicine. 2015 Apr 15;22(4):444-51. doi: 10.1016/j.phymed.2015.02.001. Epub 2015 Feb 26.
8
Salvia miltiorrhiza in Anti-diabetic Angiopathy.
Curr Mol Pharmacol. 2021;14(6):960-974. doi: 10.2174/1874467214999210111222918.
9
Danshen (Salvia miltiorrhiza) water extract shows potential neuroprotective effects in Caenorhabditis elegans.
J Ethnopharmacol. 2021 Feb 10;266:113418. doi: 10.1016/j.jep.2020.113418. Epub 2020 Sep 28.
10
Danshen: a phytochemical and pharmacological overview.
Chin J Nat Med. 2019 Jan;17(1):59-80. doi: 10.1016/S1875-5364(19)30010-X.
引用本文的文献
1
Mining the Candidate Transcription Factors Modulating Tanshinones' and Phenolic Acids' Biosynthesis Under Low Nitrogen Stress in .
Int J Mol Sci. 2025 Feb 19;26(4):1774. doi: 10.3390/ijms26041774.
2
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach.
Biogerontology. 2025 Jan 20;26(1):45. doi: 10.1007/s10522-025-10189-z.
3
Photothermally enhanced antibacterial wound healing using albumin-loaded tanshinone IIA and IR780 nanoparticles.
Front Bioeng Biotechnol. 2024 Oct 23;12:1487660. doi: 10.3389/fbioe.2024.1487660. eCollection 2024.
4
Rapid Screening of Chemical Components in with the Potential to Inhibit Skin Inflammation.
Int J Mol Sci. 2024 Jul 5;25(13):7369. doi: 10.3390/ijms25137369.
5
Protective effect of Danshensu against neurotoxicity induced by monosodium glutamate in adult mice and their offspring.
Heliyon. 2024 Feb 1;10(3):e25546. doi: 10.1016/j.heliyon.2024.e25546. eCollection 2024 Feb 15.
6
Novel Products as Promising Therapeutic Agents for Angiogenesis Inhibition.
Curr Drug Deliv. 2025;22(2):181-194. doi: 10.2174/0115672018277869231217165048.
7
Protective effects of Salvianic acid A against multiple-organ ischemia-reperfusion injury: a review.
Front Pharmacol. 2023 Nov 27;14:1297124. doi: 10.3389/fphar.2023.1297124. eCollection 2023.
8
Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I.
Heliyon. 2023 Oct 31;9(11):e21652. doi: 10.1016/j.heliyon.2023.e21652. eCollection 2023 Nov.
9
Mechanism and ingredients prediction of for retinitis pigmentosa therapy using network pharmacology and molecular docking analysis.
Ann Transl Med. 2023 Oct 25;11(11):382. doi: 10.21037/atm-22-3557. Epub 2023 Oct 7.
10
Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies.
Nat Prod Bioprospect. 2023 Oct 30;13(1):45. doi: 10.1007/s13659-023-00411-1.
本文引用的文献
1
[Stroke etiology and long-term need of care in ischemic stroke patients].
Fortschr Neurol Psychiatr. 2009 Dec;77(12):714-9. doi: 10.1055/s-0028-1109912. Epub 2009 Nov 30.
2
Effects of the aqueous extract of Salvia Miltiorrhiza (danshen) and its magnesium tanshinoate B-enriched form on blood pressure.
Phytother Res. 2010 May;24(5):769-74. doi: 10.1002/ptr.3047.
3
Inflammation in atherosclerosis: from pathophysiology to practice.
J Am Coll Cardiol. 2009 Dec 1;54(23):2129-38. doi: 10.1016/j.jacc.2009.09.009.
4
Neuron protection as a therapeutic target in acute ischemic stroke.
Curr Top Med Chem. 2009;9(14):1317-34. doi: 10.2174/156802609789869646.
5
Inflammation in ischaemic brain injury: current advances and future perspectives.
Clin Exp Pharmacol Physiol. 2010 Feb;37(2):253-8. doi: 10.1111/j.1440-1681.2009.05279.x. Epub 2009 Aug 28.
6
Inhibition of warfarin hydroxylation by major tanshinones of Danshen (Salvia miltiorrhiza) in the rat in vitro and in vivo.
Phytomedicine. 2010 Mar;17(3-4):219-26. doi: 10.1016/j.phymed.2009.05.005. Epub 2009 Jul 3.
7
Danshen extracts decrease blood C reactive protein and prevent ischemic stroke recurrence: a controlled pilot study.
Phytother Res. 2009 Dec;23(12):1721-5. doi: 10.1002/ptr.2819.
8
The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS.
J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):275-80. doi: 10.1016/j.jsbmb.2009.01.011. Epub 2009 Feb 7.
9
Patients at high risk of cerebrovascular disease: the REACH study.
Cerebrovasc Dis. 2009;27 Suppl 1:77-81. doi: 10.1159/000200443. Epub 2009 Apr 3.
10
Post-ischemic brain damage: pathophysiology and role of inflammatory mediators.
FEBS J. 2009 Jan;276(1):13-26. doi: 10.1111/j.1742-4658.2008.06766.x.
Zotero 插件