Sekine I, Sasaki Y, Hasebe T, Umeda T, Mukai K
Division of Oncology/Hematology, National Cancer Center Hospital East, Chiba, Japan.
Jpn J Clin Oncol. 1997 Oct;27(5):353-6. doi: 10.1093/jjco/27.5.353.
Primary Hodgkin's disease in the bone is extremely rare. We report the case of a 41-year-old woman with Hodgkin's disease, who had complained of left coxalgia 17 months prior to nodal involvement becoming evident clinically. She received combination chemotherapy with doxorubicin, bleomycin, vincristine and dacarbazine as well as radiotherapy to the pelvic lesion. Although the lymphadenopathy responded well to this treatment, the bone lesion was never in remission. The large mass of the bone lesion and its pelvic origin may explain the poor response to the cytotoxic therapies this patient received. The 22 cases reviewed showed that: 1, bony pain was the most frequent initial symptom; 2, nodal disease appeared in their clinical course in most cases; 3, the bones most commonly involved were pelvis, femur or tibia, and spine.
原发性骨霍奇金病极为罕见。我们报告一例41岁患霍奇金病的女性病例，该患者在临床明显出现淋巴结受累前17个月就已诉说左髋关节疼痛。她接受了阿霉素、博来霉素、长春新碱和达卡巴嗪联合化疗以及盆腔病变部位的放射治疗。尽管淋巴结病对该治疗反应良好，但骨病变从未缓解。骨病变的巨大肿块及其盆腔起源可能解释了该患者接受细胞毒性治疗效果不佳的原因。回顾的22例病例显示：1，骨痛是最常见的初始症状；2，大多数病例在其临床病程中出现淋巴结疾病；3，最常受累的骨骼是骨盆、股骨或胫骨以及脊柱。
