Betit P, Thompson J
Respiratory Care Department, Children's Hospital, Boston, Massachusetts, USA.
Respir Care Clin N Am. 1997 Sep;3(3):459-81.
The administration of NO has become an important and effective therapy in the clinical management of pulmonary hypertension associated with cardiopulmonary disorders in infants and children. It is likely to become a routine therapy in the treatment of PPHN, although dosing and timing strategies, early indicators of treatment failure, and long-term outcomes are not completely understood. The use of NO has also been beneficial in the evaluation and management of pulmonary hypertension associated with congenital heart disease. The role of NO in the management of pediatric ARDS holds promise, although further clinical trials are needed. Additional research should also be directed toward the use of NO in preterm infants and those born with CDH. Future endeavors may also include the use of NO in the evaluation and management of asthma.
一氧化氮（NO）的应用已成为婴幼儿心肺疾病相关肺动脉高压临床管理中的一种重要且有效的治疗方法。尽管给药剂量和时机策略、治疗失败的早期指标以及长期预后尚未完全明确，但它很可能成为新生儿持续性肺动脉高压（PPHN）治疗中的常规疗法。NO在先天性心脏病相关肺动脉高压的评估和管理中也具有益处。尽管还需要进一步的临床试验，但NO在小儿急性呼吸窘迫综合征（ARDS）管理中的作用也很有前景。此外，研究还应针对NO在早产儿和先天性膈疝（CDH）患儿中的应用。未来的研究方向可能还包括将NO用于哮喘的评估和管理。
