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1
Replacement of Fhit in cancer cells suppresses tumorigenicity.
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13771-6. doi: 10.1073/pnas.94.25.13771.
2
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.
Biochemistry. 1996 Sep 10;35(36):11529-35. doi: 10.1021/bi961415t.
3
Differential susceptibility of renal carcinoma cell lines to tumor suppression by exogenous Fhit expression.
Cancer Res. 2000 Jun 1;60(11):2780-5.
4
Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines.
Genes Chromosomes Cancer. 1997 Sep;20(1):16-23. doi: 10.1002/(sici)1098-2264(199709)20:1<16::aid-gcc3>3.0.co;2-c.
5
Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHIT.
J Bacteriol. 1998 May;180(9):2345-9. doi: 10.1128/JB.180.9.2345-2349.1998.
6
Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.
Cancer Res. 1997 Mar 15;57(6):1166-70.
7
FHITness and cancer.
Oncol Res. 1998;10(7):341-5.
8
Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands.
Cancer Res. 1997 Sep 1;57(17):3664-8.
9
Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma.
Genes Chromosomes Cancer. 2001 Mar;30(3):292-8. doi: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1095>3.0.co;2-f.
10
The role of deletions at the FRA3B/FHIT locus in carcinogenesis.
Recent Results Cancer Res. 1998;154:200-15. doi: 10.1007/978-3-642-46870-4_12.
引用本文的文献
1
Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair.
Exp Mol Med. 2025 Feb;57(1):167-183. doi: 10.1038/s12276-024-01374-0. Epub 2025 Jan 6.
2
Significance and implications of FHIT gene expression and promoter hypermethylation in acute lymphoblastic leukemia (ALL).
Discov Oncol. 2024 Apr 8;15(1):108. doi: 10.1007/s12672-024-00971-9.
3
Integrated analysis of gene alterations in cancer.
Cell Cycle. 2024 Jan;23(1):92-113. doi: 10.1080/15384101.2024.2304509. Epub 2024 Jan 18.
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Expression of Tumor Suppressor Is Regulated by the -SNAIL Axis in Human Lung Adenocarcinoma.
Int J Mol Sci. 2023 Nov 30;24(23):17011. doi: 10.3390/ijms242317011.
5
The Rosetta Stone Hypothesis-Based Interaction of the Tumor Suppressor Proteins Nit1 and Fhit.
Cells. 2023 Jan 17;12(3):353. doi: 10.3390/cells12030353.
6
Chemical Proteomics of the Tumor Suppressor Fhit Covalently Bound to the Cofactor ApA Elucidates Its Inhibitory Action on Translation.
J Am Chem Soc. 2022 May 18;144(19):8613-8623. doi: 10.1021/jacs.2c00815. Epub 2022 May 6.
7
Molecular Biology of the Gene That Spans Chromosomal Fragile Site .
Cells. 2021 Jun 29;10(7):1637. doi: 10.3390/cells10071637.
8
The fission yeast FHIT homolog affects checkpoint control of proliferation and is regulated by mitochondrial electron transport.
Cell Biol Int. 2020 Feb;44(2):412-423. doi: 10.1002/cbin.11241. Epub 2019 Oct 2.
9
Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.
Cell Death Dis. 2019 Feb 15;10(3):147. doi: 10.1038/s41419-019-1414-7.
10
Effects of FHIT gene on proliferation and apoptosis of osteosarcoma cells.
Oncol Lett. 2019 Jan;17(1):877-882. doi: 10.3892/ol.2018.9696. Epub 2018 Nov 14.
本文引用的文献
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The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.
Biochim Biophys Acta. 1997 Jun 7;1332(3):M65-70. doi: 10.1016/s0304-419x(97)00009-7.
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Association between cigarette smoking and FHIT gene alterations in lung cancer.
Cancer Res. 1997 Jun 1;57(11):2121-3.
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FHIT gene expression in human ovarian, endometrial, and cervical cancer cell lines.
Cancer Res. 1997 Jun 1;57(11):2112-5.
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Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins.
Nat Struct Biol. 1997 Mar;4(3):231-8. doi: 10.1038/nsb0397-231.
6
Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.
Cancer Res. 1997 Mar 15;57(6):1166-70.
7
Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B.
Hum Mol Genet. 1997 Feb;6(2):193-203. doi: 10.1093/hmg/6.2.193.
8
Structure and expression of the human FHIT gene in normal and tumor cells.
Cancer Res. 1997 Feb 1;57(3):504-12.
9
Frequent abnormalities of FHIT, a candidate tumor suppressor gene, in head and neck cancer cell lines.
Cancer Res. 1996 Nov 15;56(22):5128-31.
10
FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites.
Hum Mol Genet. 1996 Feb;5(2):187-95. doi: 10.1093/hmg/5.2.187.
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