Whetzel T P, Barnard M A
Division of Plastic and Reconstructive Surgery, University of California, Davis, Medical Center, Sacramento, USA.
Plast Reconstr Surg. 1997 Dec;100(7):1776-9. doi: 10.1097/00006534-199712000-00020.
The primary critical ischemia time of the hairless mouse ear was determined using a probit analysis. An atraumatic clamp was used across the pedicle base of the ear to induce total ischemia at 0, 2, 4, 6, 7, 7.5, 8.0, 8.5, 9.0, 9.5, and 12 hours of normothermic ischemia. Seventy-seven ears were examined 7 days after the ischemic interval for evidence of necrosis. The median critical ischemia time was determined to be 8.2 hours with 95 percent fiducial limits of 7.74 hours and 8.69 hours.
使用概率分析确定无毛小鼠耳部的主要临界缺血时间。在常温缺血0、2、4、6、7、7.5、8.0、8.5、9.0、9.5和12小时时，使用无创伤夹夹在耳部蒂基部以诱导完全缺血。在缺血间隔7天后检查77只耳朵是否有坏死迹象。确定中位临界缺血时间为8.2小时，95%置信限为7.74小时和8.69小时。
