Fujishima H, Yagi Y, Shimazaki J, Tsubota K
Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.
Cornea. 1997 Nov;16(6):630-4.
Cooling reduces acute inflammation and local nerve sensation. We investigated the relationship between artificial tear temperature, ocular surface sensation, and patient comfort.
We placed preservative-free artificial tears and eye mask stored at four temperatures (36 degrees C, 25.2 degrees C, 4 degrees C, and -10 degrees C) in the right eyes of 24 normal subjects, whose left eyes served as controls. Corneal and conjunctival sensations were measured and corneal temperature was recorded. Comfort was reported on a 7-point scale.
Corneal temperature was significantly lowered with all temperature artificial tears and frozen eye mask (p < 0.001 for each temperature relative to the previous one). Aesthesiometer readings were inversely correlated with corneal temperature (r = -0.45, p = 0.0005), decreasing with lower temperatures, reaching 2.0 +/- 1.3 g/mm2 (p = 0.001) for the mask. Conjunctival sensation reacted similarly and was well correlated with both corneal temperature (r = 0.43, p = 0.0009) and corneal sensation (r = 0.39, p = 0.006). Treatments provided relief, with the 4 degrees C tears being the most comfortable (p = 0.0001).
Although there may still be some biases, cooled artificial tears provide relief to the eye by the mechanism of reduced corneal and conjunctival sensation.
冷却可减轻急性炎症和局部神经感觉。我们研究了人工泪液温度、眼表感觉与患者舒适度之间的关系。
我们将储存在四个温度（36摄氏度、25.2摄氏度、4摄氏度和-10摄氏度）下的无防腐剂人工泪液和眼罩放置在24名正常受试者的右眼中，其左眼作为对照。测量角膜和结膜感觉并记录角膜温度。舒适度采用7分制报告。
所有温度的人工泪液和冷冻眼罩均显著降低了角膜温度（相对于前一个温度，每个温度下p<0.001）。触觉测量仪读数与角膜温度呈负相关（r=-0.45，p=0.0005），温度越低读数越低，眼罩的读数降至2.0±1.3g/mm2（p=0.001）。结膜感觉反应相似，与角膜温度（r=0.43，p=0.0009）和角膜感觉（r=0.39，p=0.006）均密切相关。治疗可缓解症状，4摄氏度的泪液最舒适（p=0.0001）。
尽管可能仍存在一些偏差，但冷却的人工泪液通过降低角膜和结膜感觉的机制为眼睛提供缓解。
