泪液半月板参数与泪膜破裂之间的关系。

Relationship between tear-meniscus parameters and tear-film breakup.

作者信息

Golding T R, Bruce A S, Mainstone J C

机构信息

Centre for Eye Research, School of Optometry, Queensland University of Technology, Australia.

出版信息

Cornea. 1997 Nov;16(6):649-61.

PMID:9395875

Abstract

PURPOSE

Several flaws exist with the lipid-diffusion model for tear-film breakup. The aim of this study was to test an alternative model of tear-film rupture in which the negative hydrostatic pressure in each tear meniscus (related to the tear-meniscus radius of curvature) is proposed to influence the formation of breaks in the tear film.

METHODS

Measurements of noninvasive breakup time (NIBUT) and tear-meniscus radius of curvature, height, width, and cross-sectional area (TMC, TMH, TMW, and XSA) were made for 15 aqueous-deficient dry-eye and 15 age-matched control subjects. An optic section of the inferior tear meniscus (colored with a minute volume of fluorescein) was photographed at x120 magnification, and images were computer analyzed.

RESULTS

A significant positive correlation was found between log NIBUT and TMC (r2 = 0.141; p < 0.05). Furthermore, all subjects with TMC < 0.340 mm had NIBUT < 15 s, and two thirds of subjects with TMC > 0.340 mm had NIBUT > 15 s. There was a moderate linear relationship between TMH and log NIBUT, indicating an association between tear volume and tear stability. TMC, TMH, and tear meniscus XSA measurements all showed good reliability.

CONCLUSIONS

The association between highly curved tear menisci and rapid tear-film breakup times is consistent with the meniscus model of tear-film rupture. However, a causal relationship has yet to be established.

摘要

目的

泪膜破裂的脂质扩散模型存在若干缺陷。本研究的目的是测试一种泪膜破裂的替代模型，该模型提出每个泪液弯月面中的负静水压力（与泪液弯月面的曲率半径相关）会影响泪膜破裂的形成。

方法

对15名水样液缺乏型干眼患者和15名年龄匹配的对照受试者进行了无创破裂时间（NIBUT）以及泪液弯月面的曲率半径、高度、宽度和横截面积（TMC、TMH、TMW和XSA）的测量。以120倍放大率拍摄下泪液弯月面的光学切片（用微量荧光素染色），并对图像进行计算机分析。

结果

发现log NIBUT与TMC之间存在显著正相关（r2 = 0.141；p < 0.05）。此外，所有TMC < 0.340 mm的受试者NIBUT < 15 s，而三分之二TMC > 0.340 mm的受试者NIBUT > 15 s。TMH与log NIBUT之间存在中度线性关系，表明泪液体积与泪液稳定性之间存在关联。TMC、TMH和泪液弯月面XSA测量均显示出良好的可靠性。