Widmer J, Mouthon D, Raffin Y, Chollet D, Hilleret H, Malafosse A, Bovier P
Hôpitaux Universitaires de Genève, Département de Psychiatrie, Chêne-Bourg, Genève, Switzerland.
Neuropsychobiology. 1997;36(4):164-71. doi: 10.1159/000119378.
In previous reports, we showed that plasma and erythrocyte magnesium were increased in many drug-free hospitalized depressed patients. Furthermore, we observed that erythrocyte magnesium content was related to the intensity of the symptoms. Highly depressed patients had the highest magnesium values. Today, we report the results of plasma and erythrocyte sodium and potassium, and of total and ultrafilterable plasma calcium in 66 hospitalized patients with major depression compared to 58 healthy controls. No consistent differences in these biochemical parameters are observed between patients when separated according to intensity of anxiety, psychomotor retardation, and moral distress. Plasma sodium is higher and plasma potassium lower in female patients of all subgroups as compared to controls. Both male patients and controls have erythrocyte sodium and potassium levels that are significantly different from those of females. This clearly suggests a separation into genders in such studies. In conclusion--in contrast to blood magnesium--sodium, potassium, and calcium levels do not seem to be related to the intensity of the main clinical symptoms in hospitalized patients with major depression.
在先前的报告中，我们表明许多未服用药物的住院抑郁症患者血浆和红细胞中的镁含量增加。此外，我们观察到红细胞镁含量与症状强度有关。重度抑郁症患者的镁值最高。如今，我们报告了66例住院重度抑郁症患者与58例健康对照者的血浆和红细胞钠、钾以及血浆总钙和超滤性钙的检测结果。根据焦虑强度、精神运动迟缓程度和精神痛苦程度对患者进行分组时，未观察到这些生化参数存在一致差异。与对照组相比，所有亚组的女性患者血浆钠较高而血浆钾较低。男性患者和对照组的红细胞钠和钾水平均与女性患者有显著差异。这清楚地表明在这类研究中应按性别分组。总之，与血镁不同，钠、钾和钙水平似乎与住院重度抑郁症患者的主要临床症状强度无关。
