Costa J J, Weller P F, Galli S J
JAMA. 1997 Dec 10;278(22):1815-22.
Mast cells, basophils, and eosinophils have long been regarded as important effector cells in allergic disorders. Indeed, it is thought that the cells' cytoplasmic granule-associated or lipid mediators contribute to many of the signs and symptoms that are characteristic of these diseases. Mast cells, basophils, and eosinophils also probably contribute to protective host responses, especially to parasites. In addition, recent evidence shows that mast cells, basophils, and eosinophils can secrete a wide spectrum of cytokines and, in some cases, express functions that may permit them to regulate the development or perpetuation of allergic responses. Thus, mast cells, basophils, and eosinophils may express immunoregulatory activities, as well as serve as effector cells.
肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞长期以来一直被视为过敏性疾病中的重要效应细胞。事实上，人们认为这些细胞的细胞质颗粒相关介质或脂质介质导致了这些疾病许多典型的体征和症状。肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞可能也有助于宿主的保护性反应，尤其是对寄生虫的反应。此外，最近的证据表明，肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞可以分泌多种细胞因子，在某些情况下，还表现出可能使其调节过敏反应发展或持续的功能。因此，肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞可能不仅发挥效应细胞的作用，还具有免疫调节活性。
