Molina I, Baars S, Brill J A, Hales K G, Fuller M T, Ripoll P
Centro de Biología Molecular "Severo Ochoa" Consejo Superior Investigaciones Científicas-Universidad Autónoma Madrid, Facultad de Ciencias, UAM, Cantoblanco, 28049 Madrid, Spain.
J Cell Biol. 1997 Dec 15;139(6):1361-71. doi: 10.1083/jcb.139.6.1361.
The tiovivo (tio) gene of Drosophila encodes a kinesin-related protein, KLP38B, that colocalizes with condensed chromatin during cell division. Wild-type function of the tio gene product KLP38B is required for normal chromosome segregation during mitosis. Mitotic cells in tio larval brains displayed circular mitotic figures, increased ploidy, and abnormal anaphase figures. KLP38B mRNA is maternally provided and expressed in cells about to undergo division. We propose that KLP38B, perhaps redundantly with other chromosome-associated microtubule motor proteins, contributes to interactions between chromosome arms and microtubules important for establishing bipolar attachment of chromosomes and assembly of stable bipolar spindles.
果蝇的tiovivo（tio）基因编码一种与驱动蛋白相关的蛋白质KLP38B，该蛋白在细胞分裂期间与浓缩染色质共定位。tio基因产物KLP38B的野生型功能是有丝分裂期间正常染色体分离所必需的。tio幼虫大脑中的有丝分裂细胞呈现圆形有丝分裂图像、多倍体增加和后期图像异常。KLP38B mRNA由母体提供并在即将进行分裂的细胞中表达。我们提出，KLP38B可能与其他与染色体相关的微管运动蛋白冗余，有助于染色体臂与微管之间的相互作用，这对于建立染色体的双极附着和稳定双极纺锤体的组装很重要。
