Mason Stephen B, Lai Xianyin, Bacallao Robert L, Blazer-Yost Bonnie L, Gattone Vincent H, Wang Kevin C, Witzmann Frank A
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Proteomics Clin Appl. 2009 Jun 24;3(10):1247-1250. doi: 10.1002/prca.200800163.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the development of numerous fluid-filled cysts in the kidneys of patients. We recently published our description of the proteome of renal cyst fluid in ADPKD. As a follow-up experiment, we hypothesized that the protein-bound subfraction consists of molecules of mechanistic or diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified 44 distinct proteins in human cyst fluid.
常染色体显性多囊肾病（ADPKD）的特征是患者肾脏中出现大量充满液体的囊肿。我们最近发表了对ADPKD肾囊肿液蛋白质组的描述。作为后续实验，我们假设蛋白质结合亚组分包含对ADPKD具有机制或诊断意义的分子。使用手动生物标志物富集试剂盒，我们在人囊肿液中鉴定出了44种不同的蛋白质。
