常染色体显性多囊肾病囊肿液中富含生物标志物的蛋白质组
The biomarker enriched proteome of autosomal dominant polycystic kidney disease cyst fluid.
作者信息
Mason Stephen B, Lai Xianyin, Bacallao Robert L, Blazer-Yost Bonnie L, Gattone Vincent H, Wang Kevin C, Witzmann Frank A
机构信息
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Proteomics Clin Appl. 2009 Jun 24;3(10):1247-1250. doi: 10.1002/prca.200800163.
Abstract
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the development of numerous fluid-filled cysts in the kidneys of patients. We recently published our description of the proteome of renal cyst fluid in ADPKD. As a follow-up experiment, we hypothesized that the protein-bound subfraction consists of molecules of mechanistic or diagnostic interest in ADPKD. Using a manual biomarker enrichment kit, we have identified 44 distinct proteins in human cyst fluid.
摘要
常染色体显性多囊肾病（ADPKD）的特征是患者肾脏中出现大量充满液体的囊肿。我们最近发表了对ADPKD肾囊肿液蛋白质组的描述。作为后续实验，我们假设蛋白质结合亚组分包含对ADPKD具有机制或诊断意义的分子。使用手动生物标志物富集试剂盒，我们在人囊肿液中鉴定出了44种不同的蛋白质。
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本文引用的文献
1
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Proteomics Clin Appl. 2008 Jul 1;2(7-8):1140-1152. doi: 10.1002/prca.200780140.
2
Investigation of an albumin-enriched fraction of human serum and its albuminome.人血清富含白蛋白组分及其白蛋白组的研究。
Proteomics Clin Appl. 2007 Jan 1;1(1):73-88. doi: 10.1002/prca.200600276.
3
Overexpression of innate immune response genes in a model of recessive polycystic kidney disease.隐性多囊肾病模型中固有免疫反应基因的过表达
Kidney Int. 2008 Jan;73(1):63-76. doi: 10.1038/sj.ki.5002627. Epub 2007 Oct 24.
4
Autosomal dominant polycystic kidney disease.常染色体显性多囊肾病
Lancet. 2007 Apr 14;369(9569):1287-1301. doi: 10.1016/S0140-6736(07)60601-1.
5
Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.多囊蛋白-1或多囊蛋白-2的缺失通过核激素受体的改变导致小鼠组织中载脂蛋白表达失调。
Hum Mol Genet. 2006 Jan 1;15(1):11-21. doi: 10.1093/hmg/ddi421. Epub 2005 Nov 21.
6
Effective removal of albumin from serum.有效去除血清中的白蛋白。
Proteomics. 2005 Oct;5(15):3831-5. doi: 10.1002/pmic.200401235.
7
An investigation into the human serum "interactome".
Electrophoresis. 2004 May;25(9):1289-98. doi: 10.1002/elps.200405866.
8
Excretion of epidermal growth factor in human adult polycystic kidney disease.成人多囊肾疾病中表皮生长因子的排泄
Isr J Med Sci. 1997 Oct;33(10):641-2.
9
Immunoreactive epidermal growth factor in serum, plasma, platelets, and urine in patients on chronic dialysis.慢性透析患者血清、血浆、血小板及尿液中的免疫反应性表皮生长因子
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