一种将转录与剪接联系起来的CTD功能。
A CTD function linking transcription to splicing.
作者信息
Corden J L, Patturajan M
机构信息
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Trends Biochem Sci. 1997 Nov;22(11):413-6. doi: 10.1016/s0968-0004(97)01125-0.
Since its discovery in 1985, the function of the C-terminal domain (CTD) of RNA polymerase II has been a puzzle. Recent studies suggest that the CTD functions as a linear platform for assembly of complexes that splice, cleave and polyadenylate pre-mRNA. A new set of CTD-associated SR-like proteins (CASPs) have been implicated in pre-mRNA processing and transcription elongation as a component of the emerging 'transcriptosome'.
自1985年被发现以来，RNA聚合酶II的C末端结构域（CTD）的功能一直是个谜。最近的研究表明，CTD作为一个线性平台，用于组装对前体mRNA进行剪接、切割和聚腺苷酸化的复合物。一组新的与CTD相关的SR样蛋白（Casp）作为新兴的“转录体”的一个组成部分，参与了前体mRNA的加工和转录延伸。
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