DNA聚合酶α-引发酶复合体将DNA复制、细胞周期进程和DNA损伤反应联系在一起。
The DNA polymerase alpha-primase complex couples DNA replication, cell-cycle progression and DNA-damage response.
作者信息
Foiani M, Lucchini G, Plevani P
机构信息
Dipartimento di Genetica e di Biologia dei Microrganismi, Università degli Studi di Milano, Italy.
出版信息
Trends Biochem Sci. 1997 Nov;22(11):424-7. doi: 10.1016/s0968-0004(97)01109-2.
The highly conserved DNA polymerase alpha-primase complex (pol-prism) is the only eukaryotic DNA polymerase that can initiate DNA synthesis de novo. It is required both for the initiation of DNA replication at chromosomal origins and for the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. The dual role of pol-prim makes it a likely target for mechanisms that control cell-cycle S-phase entry and progression.
高度保守的DNA聚合酶α-引发酶复合体（pol-prism）是唯一能够从头起始DNA合成的真核生物DNA聚合酶。它对于染色体复制起点处的DNA复制起始以及复制叉后随链上冈崎片段的不连续合成均是必需的。pol-prim的双重作用使其成为控制细胞周期S期进入和进程机制的一个可能靶点。
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