Gonera E G, van't Hof M, Berger H J, van Weel C, Horstink M W
Department of Neurology, University Hospital Nijmegen, The Netherlands.
Mov Disord. 1997 Nov;12(6):871-6. doi: 10.1002/mds.870120607.
To investigate the duration of a prodromal phase before the onset of the classic symptoms of idiopathic Parkinson's disease, the authors conducted a retrospective case-control study of 60 patients with Parkinson's disease and 58 age- and sex-matched control subjects, covering the decade preceding the onset of classic Parkinson's disease. The symptoms were derived from files of the patients' general practitioners. Compared with control subjects, patients pre-Parkinson's disease had more central nervous system, psychologic, musculoskeletal, and cardiovascular (i.e., autonomic) symptoms. Patients pre-Parkinson's disease also made more visits to general practitioners and medical specialists. The results indicate that the onset of classic parkinsonism is frequently preceded by a prodromal phase lasting from 4-6 years.
为了研究特发性帕金森病典型症状出现之前前驱期的持续时间，作者对60例帕金森病患者和58例年龄及性别匹配的对照者进行了一项回顾性病例对照研究，研究涵盖了典型帕金森病发病前的十年。症状来源于患者全科医生的档案。与对照者相比，帕金森病前驱期患者有更多的中枢神经系统、心理、肌肉骨骼和心血管（即自主神经）症状。帕金森病前驱期患者看全科医生和医学专家的次数也更多。结果表明，典型帕金森综合征的发病之前常有一个持续4至6年的前驱期。
