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与急性颅内血肿相关的帕金森综合征:一项[18F]多巴正电子发射断层扫描研究。

Parkinsonism associated with acute intracranial hematomas: an [18F]dopa positron-emission tomography study.

作者信息

Turjanski N, Pentland B, Lees A J, Brooks D J

机构信息

MRC Cyclotron Unit, Hammersmith Hospital, London, England, U.K.

出版信息

Mov Disord. 1997 Nov;12(6):1035-8. doi: 10.1002/mds.870120630.

Abstract

We present the case of a 36-year-old woman with a right temporal hematoma and an overlying subdural hematoma following rupture of a right middle cerebral artery aneurysm. Three weeks after recovering consciousness, she developed a levodopa-responsive parkinsonian syndrome involving the right limbs. A year after the vascular event, she reported subjective improvement in her parkinsonism, which has remained stable since. 18F-dopa positron-emission tomography showed a marked reduction of uptake in the left putamen, raising the possibility that the intracranial hemorrhage unmasked latent Parkinson's disease. To the best of our knowledge, this is the first case of parkinsonism associated with spontaneous acute intracerebral and subdural hematomas.

摘要

我们报告了一例36岁女性病例,该患者因右侧大脑中动脉瘤破裂出现右侧颞叶血肿及硬膜下血肿。意识恢复三周后,她出现了累及右侧肢体的左旋多巴反应性帕金森综合征。血管事件发生一年后,她报告帕金森症状主观上有所改善,此后一直保持稳定。18F-多巴正电子发射断层扫描显示左侧壳核摄取明显减少,提示颅内出血可能使潜在的帕金森病显现出来。据我们所知,这是首例与自发性急性脑内和硬膜下血肿相关的帕金森综合征病例。

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