Elitsur Y, Triest W E
Department of Pediatrics, Cabell Huntington Hospital, Marshall University School of Medicine, Huntington, West Virginia 25701-0195, USA.
Am J Gastroenterol. 1997 Dec;92(12):2216-9.
Duodenal gastric metaplasia (DGM) is commonly found in association with Helicobacter pylori (Hp)-associated gastritis in adults. DGM is also considered a risk factor for duodenal ulcer development. The prevalence of DGM in children and its association with gastritis, duodenitis, or the presence of Hp organisms is not clear. We investigated the prevalence of DGM in children and explore its association with several possible risk factors, including age, gender, gastritis, duodenitis, or Hp presence in the gastric antrum.
A retrospective analysis of 173 upper endoscopy procedures performed between 1993 and 1995 at Cabell Huntington Hospital, Huntington, WV, was done. Gastric and duodenal biopsies were stained with Giemsa for Hp detection, periodic acid-Schiff for DGM, and hematoxylin and eosin for histologic assessment. Gastric mucosal inflammation was graded according to Sydney criteria.
Duodenal gastric metaplasia was identified in 23 of 173 (13%) patients. Duodenitis but not age, gender, gastritis, or the presence of Hp in the gastric antrum was associated with DGM development. In 4 of 23 DGM foci, Hp was identified.
In children, DGM is not the consequence of Hp infection.
十二指肠胃化生（DGM）常见于成人幽门螺杆菌（Hp）相关性胃炎。DGM也被认为是十二指肠溃疡发生的危险因素。儿童DGM的患病率及其与胃炎、十二指肠炎或Hp感染的关系尚不清楚。我们调查了儿童DGM的患病率，并探讨其与几种可能危险因素的关系，包括年龄、性别、胃炎、十二指肠炎或胃窦部Hp感染情况。
对1993年至1995年间在西弗吉尼亚州亨廷顿市卡贝尔亨廷顿医院进行的173例上消化道内镜检查进行回顾性分析。胃和十二指肠活检组织用吉姆萨染色检测Hp，用高碘酸-希夫染色检测DGM，并用苏木精和伊红染色进行组织学评估。胃黏膜炎症根据悉尼标准分级。
173例患者中有23例（13%）发现十二指肠胃化生。十二指肠炎而非年龄、性别、胃炎或胃窦部Hp感染与DGM的发生有关。在23个DGM病灶中的4个发现了Hp。
在儿童中，DGM不是Hp感染的结果。
