腹膜内研究中纤维性粉尘的剂量-反应关系。
Dose-response relationship of fibrous dusts in intraperitoneal studies.
作者信息
Roller M, Pott F, Kamino K, Althoff G H, Bellmann B
机构信息
Department of Experimental Hygiene, Heinrich Heine University, Düsseldorf, Germany.
出版信息
Environ Health Perspect. 1997 Sep;105 Suppl 5(Suppl 5):1253-6. doi: 10.1289/ehp.97105s51253.
The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies with several fibrous dusts. Based on observed tumor incidences ranging between 10 and 90%, the hypothesis of a common slope of dose-response relationships (parallel probit lines in probit analysis) cannot be rejected. In general, parallelism of probit lines is considered an indication of a common mode of action. Analysis of the shape of the dose-response relationship, with one apparent exception, shows virtually linear or superlinear behavior, i.e., from these data, there is no indication of a decrease in carcinogenic potency of an elementary carcinogenic unit at lower doses.
利用一系列针对几种纤维性粉尘的致癌性研究数据，研究了腹腔内注射纤维数量与大鼠腹膜间皮瘤发生之间的关系。基于观察到的肿瘤发生率在10%至90%之间，剂量反应关系的共同斜率假说（概率分析中的平行概率线）不能被拒绝。一般来说，概率线的平行性被认为是共同作用模式的一个指标。对剂量反应关系形状的分析，有一个明显的例外，几乎显示出线性或超线性行为，即从这些数据来看，没有迹象表明在较低剂量下基本致癌单位的致癌效力会降低。
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