Davis J M, Bolton R E, Miller B G, Niven K
Institute of Occupational Medicine Ltd, Edinburgh.
Int J Exp Pathol. 1991 Jun;72(3):263-74.
The relationship between injected dose and the development of peritoneal mesotheliomas has been examined in rats using the UTCC standard reference samples of chrysotile, crocidolite and amosite as well as a sample of fibrous erionite from Oregon. Doses injected into the peritoneal cavity ranged from 0.005 to 25 mg and with each dust a clear dose response was found. The proportion of animals developing tumours increased with the amount of dust injected while the tumour induction period was reduced. When times to death from mesothelioma were analysed using standard hazard models, erionite was the most carcinogenic dust by mass followed by chrysotile, amosite and crocidolite. The hazard slopes for erionite, chrysotile and crocidolite, over the range of doses examined, were parallel while the slope for amosite was shallower. The relative hazards for the various dust types were also examined with dose expressed as the number of injected fibres in a range of sizes as measured by SEM. No combination of fibre dimensions was found at which the hazard for the four dust types was equal although when dose was expressed as the number of long fibres injected (> 8 microns in length) the hazard slopes for chrysotile, crocidolite and amosite were relatively close. The hazard level of erionite remained well above the other dust types regardless of how the dose was expressed.
利用温石棉、青石棉和铁石棉的UTCC标准参考样品以及来自俄勒冈州的纤维水硅钙石样品，在大鼠身上研究了注射剂量与腹膜间皮瘤发生之间的关系。注入腹腔的剂量范围为0.005至25毫克，每种粉尘都呈现出明显的剂量反应。患肿瘤动物的比例随着注入粉尘量的增加而上升，同时肿瘤诱导期缩短。当使用标准风险模型分析因间皮瘤死亡的时间时，按质量计算，水硅钙石是最具致癌性的粉尘，其次是温石棉、铁石棉和青石棉。在所研究的剂量范围内，水硅钙石、温石棉和青石棉的风险斜率是平行的，而铁石棉的斜率较平缓。还以扫描电子显微镜测量的一系列尺寸的注入纤维数量来表示剂量，研究了各种粉尘类型的相对风险。尽管当剂量以注入的长纤维数量（长度>8微米）表示时，温石棉、青石棉和铁石棉的风险斜率相对接近，但未发现纤维尺寸的任何组合能使四种粉尘类型的风险相等。无论剂量如何表示，水硅钙石的风险水平都远高于其他粉尘类型。
