Crawley J N
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, MD 20892-1380, USA.
Life Sci. 1996;58(24):2185-99. doi: 10.1016/0024-3205(96)00093-8.
The neuropeptide, galanin, and its receptors are localized in the cholinergic basal forebrain and its projection areas in mammalian brain. Centrally administered galanin inhibits acetylcholine release in the rat ventral hippocampus, and produces deficits in learning and memory tasks. In Alzheimer's disease, galanin is overexpressed in terminals innervating the nucleus basalis of Meynert cell bodies. Selective galanin receptor antagonists provide a novel approach for increasing cholinergic function, as a potential adjunct to the clinical treatment of dementias.
神经肽甘丙肽及其受体定位于哺乳动物脑内的胆碱能基底前脑及其投射区域。脑室内注射甘丙肽可抑制大鼠腹侧海马区乙酰胆碱的释放，并导致学习和记忆任务受损。在阿尔茨海默病中，甘丙肽在支配梅纳特基底核细胞体的终末中过度表达。选择性甘丙肽受体拮抗剂为增强胆碱能功能提供了一种新方法，可作为痴呆临床治疗的潜在辅助手段。
