Appels A
Department of Medical Psychology, University of Maastricht, The Netherlands.
Acta Physiol Scand Suppl. 1997;640:153-4.
A state of 'vital exhaustion', characterized by unusual tiredness, increased irritability and feelings of demoralization has been found to preceed the onset of myocardial infarction and to increase the risk of a new coronary event after angioplasty. Probably this state reflects a decreased activity of the hypothalamic-pituitary-adrenal axis as part of an homeostatic reaction to prolonged stress and inflammation.
一种“活力耗竭”状态，其特征为异常疲劳、易怒加剧和士气低落，已被发现先于心肌梗死发作，并增加血管成形术后发生新的冠状动脉事件的风险。这种状态可能反映了下丘脑 - 垂体 - 肾上腺轴的活性降低，这是对长期压力和炎症的一种稳态反应的一部分。
