Barrio R, Roldán M B, Alonso M, Cantón R, Camarero C
Department of Pediatrics, Ramón y Cajal Hospital, Alcalá de Henares University School of Medicine, Madrid, Spain.
J Pediatr Endocrinol Metab. 1997 Sep-Oct;10(5):511-6. doi: 10.1515/jpem.1997.10.5.511.
One hundred and seventy-seven patients with insulin dependent diabetes mellitus (IDDM) diagnosed at the pediatric age were investigated for the presence of gastric parietal cell autoantibodies (PCA). The objective was to evaluate the prevalence of PCA seropositivity and to know whether Helicobacter pylori could be a reason for a higher presence of PCA in IDDM children and adolescents. Twelve of 177 patients (6.77%; confidence interval: 3.1-10.3) had detectable PCA. Gastric pathology was studied in eight of these patients and in seven patients without PCA. Diagnosis of H. pylori infection was made on antral biopsies. None of the patients had an atrophic gastritis. Six of the eight patients with PCA had gastric mucosa colonization by H. pylori and/or chronic gastritis. According to these results, we suggest that H. pylori can be the cause of the presence of PCA positive results in diabetic children and adolescents, and diabetic patients with detectable PCA should be screened for H. pylori.
对177例在儿童期被诊断为胰岛素依赖型糖尿病（IDDM）的患者进行了胃壁细胞自身抗体（PCA）检测。目的是评估PCA血清阳性的患病率，并了解幽门螺杆菌是否可能是IDDM儿童和青少年中PCA较高存在率的原因。177例患者中有12例（6.77%；置信区间：3.1-10.3）可检测到PCA。对其中8例有PCA的患者和7例无PCA的患者进行了胃部病理研究。通过胃窦活检诊断幽门螺杆菌感染。所有患者均无萎缩性胃炎。8例有PCA的患者中有6例胃黏膜有幽门螺杆菌定植和/或慢性胃炎。根据这些结果，我们认为幽门螺杆菌可能是糖尿病儿童和青少年中PCA阳性结果存在的原因，对于可检测到PCA的糖尿病患者应筛查幽门螺杆菌。
