Freedman B I, Soucie J M, McClellan W M
Department of Internal Medicine/Nephrology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1053, USA.
J Am Soc Nephrol. 1997 Dec;8(12):1942-5. doi: 10.1681/ASN.V8121942.
As part of a larger study of genetic risk factors for the occurrence of renal failure, the prevalence of a family history of end-stage renal disease (ESRD) in first- and second-degree relatives of all incident dialysis patients treated in Georgia, North Carolina, and South Carolina (ESRD Network 6) in 1994 was ascertained. Family histories were obtained from 4365 dialysis patients (83% of those eligible), and 856 (20%) reported having a family history of ESRD. Among race-sex groups, 14.1% of Caucasian men, 14.6% of Caucasian women, 22.9% of African-American men, and 23.9% of African-American women reported a first- or second-degree relative with ESRD (P = 0.001). The prevalence of relatives with ESRD varied by the reported etiology: 22.2% in diabetes mellitus; 18.9% in hypertension, 22.7% in glomerulonephritis; and 13.0% of other etiologies (P = 0.001). Patient characteristics independently associated with family history of ESRD included race, younger age, higher levels of education, and etiology of ESRD. In this report, it is concluded that a large proportion of incident ESRD cases have close relatives with ESRD in whom preventive actions might be directed. Genetic analyses in multiply affected families may identify the inherited factors contributing to progressive renal failure.
作为一项关于肾衰竭发生的遗传风险因素的更大规模研究的一部分，确定了1994年在佐治亚州、北卡罗来纳州和南卡罗来纳州（终末期肾病网络6）接受治疗的所有新发透析患者的一级和二级亲属中终末期肾病（ESRD）家族史的患病率。从4365名透析患者（占 eligible人数的83%）获取了家族史，其中856人（20%）报告有ESRD家族史。在不同种族 - 性别组中，14.1%的白人男性、14.6%的白人女性、22.9%的非裔美国男性和23.9%的非裔美国女性报告有一级或二级亲属患有ESRD（P = 0.001）。患有ESRD的亲属患病率因报告的病因不同而有所差异：糖尿病患者中为22.2%；高血压患者中为18.9%，肾小球肾炎患者中为22.7%；其他病因患者中为13.0%（P = 0.001）。与ESRD家族史独立相关的患者特征包括种族、年龄较小、教育程度较高以及ESRD的病因。在本报告中，得出的结论是，很大一部分新发ESRD病例有患有ESRD的近亲，针对这些近亲可能采取预防措施。对多个患病家庭进行基因分析可能会确定导致进行性肾衰竭的遗传因素。
