Hata T, Senoh D, Hata K, Miyazaki K
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
Hum Reprod. 1997 Oct;12(10):2286-91. doi: 10.1093/humrep/12.10.2286.
Our purpose was to evaluate embryonic heart diameter in early first-trimester pregnancy using intrauterine sonography with a 20 MHz flexible catheter-based high-resolution real-time miniature transducer. A total of 40 women about to undergo therapeutic abortion from 6-9.9 weeks gestational age and one abnormal pregnancy with fetal hydrops at 9 weeks were studied with a specially developed catheter-based high-resolution real-time miniature (2.4 mm outer diameter) ultrasound transducer (20 MHz). A curvilinear relationship was found between the menstrual age and embryonic heart diameter (R2 = 95.7%), and a normal range of embryonic heart diameter for estimating the growth of the embryonic heart during early first-trimester pregnancy was generated. A normogram of menstrual age as predicted by embryonic heart diameter was also established. There was a good curvilinear correlation between embryonic heart diameter and crown-rump length (R2 = 90.1%). The embryonic heart diameter/crown-rump length ratio rapidly decreased from week 6 to week 7, and remained almost constant thereafter. Embryonic heart diameter (5.2 mm) in the case of fetal hydrops at 9 weeks was above the normal range. These results may provide an additional method of estimating gestational age in the early first trimester of pregnancy. In this limited series, a single case of embryonic heart enlargement was demonstrated, suggesting its potential use in the detection of embryonic congestive heart failure.
我们的目的是使用基于20 MHz柔性导管的高分辨率实时微型换能器的宫内超声检查来评估孕早期的胚胎心脏直径。对40名妊娠6至9.9周即将接受治疗性流产的妇女以及1例9周时胎儿水肿的异常妊娠进行了研究，使用了专门开发的基于导管的高分辨率实时微型（外径2.4 mm）超声换能器（20 MHz）。发现月经年龄与胚胎心脏直径之间存在曲线关系（R2 = 95.7%），并得出了孕早期胚胎心脏生长的胚胎心脏直径正常范围。还建立了根据胚胎心脏直径预测月经年龄的标准曲线。胚胎心脏直径与头臀长度之间存在良好的曲线相关性（R2 = 90.1%）。胚胎心脏直径/头臀长度比值从第6周迅速下降至第7周，此后几乎保持恒定。9周时胎儿水肿病例的胚胎心脏直径（5.2 mm）高于正常范围。这些结果可能为孕早期估计孕周提供一种额外的方法。在这个有限的系列中，展示了1例胚胎心脏增大的病例，提示其在检测胚胎充血性心力衰竭方面的潜在用途。
