Edelstein C, Shields J A, Shields C L, De Potter P, Eagle R C, Turtel L, Hagstrom N
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Am J Ophthalmol. 1997 Dec;124(6):859-61. doi: 10.1016/s0002-9394(14)71714-3.
To report an unusual case of orbital involvement with non-African Burkitt lymphoma in a child.
A 26-month-old boy developed oral thrush and painless right proptosis with eyelid swelling. Magnetic resonance imaging disclosed a diffuse mass involving the inferior, lateral, and superior right orbit and both maxillary sinuses. Incisional biopsy of the orbital mass was performed.
Histopathology disclosed diffuse infiltration of the orbital tissues by a high-grade lymphoid neoplasm that showed positive immunoreactivity for B-cell markers. Immunoglobulin gene rearrangement studies disclosed a characteristic t(8;14) translocation consistent with a small, noncleaved malignant lymphoma of the Burkitt type.
Non-African Burkitt lymphoma may manifest with orbital involvement.
报告1例儿童非非洲型伯基特淋巴瘤累及眼眶的罕见病例。
一名26个月大的男孩出现口腔鹅口疮及右侧无痛性眼球突出伴眼睑肿胀。磁共振成像显示一个弥漫性肿块累及右侧眼眶下、外侧及上半部分以及双侧上颌窦。对眼眶肿块进行了切开活检。
组织病理学显示眼眶组织被一种高级别淋巴样肿瘤弥漫浸润，该肿瘤对B细胞标志物呈阳性免疫反应。免疫球蛋白基因重排研究显示特征性的t(8;14)易位，符合伯基特型小无裂恶性淋巴瘤。
非非洲型伯基特淋巴瘤可能表现为眼眶受累。
