Shindo K
First Department of Surgery, Kinki University, Osaka, Japan.
Dermatology. 1997;195 Suppl 2:78-84. doi: 10.1159/000246036.
No definite guidelines have been published concerning the suitable exposure time and frequency of skin antisepsis of the operative field. In the present study, the antiseptic effect of a single use (single-application group) of 10% povidoneiodine solution for skin antisepsis was compared with its triple use (triple-application group). The exposure time was 2 min for both groups. Moreover, the effects on blood levels of total iodine and thyroid-gland-related substances were evaluated. High antiseptic efficacy was obtained in both groups, indicating that our antiseptic method to disinfect the operative field is effective. Slightly better results were obtained from the triple-application group, although the difference was not statistically significant. Blood levels of total iodine and thyroid-gland-related substances remained within the normal range in all cases. However, in cases receiving a large amount of 10% povidone-iodine solution a transient elevation in blood total iodine was observed. Thus, the 10% povidone-iodine solution is considered to be safe and effective for skin antisepsis of the operative field when applied repeatedly in a small amount per dose with an exposure time of about 2 min.
关于手术区域皮肤消毒的适宜暴露时间和频率，尚未发布明确的指南。在本研究中，将单次使用（单次涂抹组）10%聚维酮碘溶液进行皮肤消毒的抗菌效果与其三次使用（三次涂抹组）的抗菌效果进行了比较。两组的暴露时间均为2分钟。此外，还评估了对总碘和甲状腺相关物质血液水平的影响。两组均获得了较高的抗菌效果，表明我们对手术区域进行消毒的抗菌方法是有效的。三次涂抹组的结果略好，尽管差异无统计学意义。所有病例中总碘和甲状腺相关物质的血液水平均保持在正常范围内。然而，在接受大量10%聚维酮碘溶液的病例中，观察到血液总碘有短暂升高。因此，当以约2分钟的暴露时间、每次少量重复应用时，10%聚维酮碘溶液被认为对手术区域的皮肤消毒是安全有效的。
