Sinaiko A R, Gomez-Marin O, Prineas R J
Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455, USA.
Hypertension. 1997 Dec;30(6):1554-9. doi: 10.1161/01.hyp.30.6.1554.
This study was intended to clarify the relation between fasting insulin, lipids, and blood pressure in adolescents before the onset of hypertension and to examine the association of these data with similar data obtained in their parents. The participants in this study were 183 adolescents 14 to 18 years old (96 girls) completing a 4-year intervention trial and their parents (164 mothers, 122 fathers). Blood pressure was measured twice on the right arm in a seated position using a random-zero sphygmomanometer. Fasting blood samples were obtained for lipid and insulin analyses. Fasting insulin was significantly correlated with systolic blood pressure in the adolescents and also in the parents before and after adjustment for body mass index. Fasting insulin was correlated significantly with levels of cholesterol, triglycerides, and HDL and LDL cholesterol in the adolescents. It was correlated only with triglycerides and HDL-cholesterol in mothers and fathers. After adjustment for body mass index, the correlations between fasting insulin and lipids in the children were not significant. A significant relation was shown between children's systolic blood pressure and mothers' fasting insulin and systolic blood pressure. Significant correlations were found between the children's and fathers' triglycerides and HDL-cholesterol, whereas significant correlations were found for fasting insulin and all lipids between mothers and children, and these remained significant after adjustment for body mass index. These results show (1) a significant relation between fasting insulin and both lipids and systolic blood pressure in adolescents and (2) a significant relation for these factors between adolescents and their parents. Although weight appears to play an important role in this relation during adolescence, genetic and environmental factors other than those mediated via weight may control insulin metabolism within families. The data support a role for studies during early biological development to address these issues.
本研究旨在阐明高血压发病前青少年空腹胰岛素、血脂与血压之间的关系，并检验这些数据与他们父母的类似数据之间的关联。本研究的参与者为183名14至18岁的青少年（96名女孩），他们完成了一项为期4年的干预试验，以及他们的父母（164名母亲，122名父亲）。使用随机零点血压计，在坐位时测量右臂血压两次。采集空腹血样进行血脂和胰岛素分析。在调整体重指数前后，青少年及其父母的空腹胰岛素与收缩压均显著相关。青少年的空腹胰岛素与胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白胆固醇水平显著相关。在母亲和父亲中，它仅与甘油三酯和高密度脂蛋白胆固醇相关。调整体重指数后，儿童空腹胰岛素与血脂之间的相关性不显著。儿童收缩压与母亲的空腹胰岛素和收缩压之间存在显著关系。儿童与父亲的甘油三酯和高密度脂蛋白胆固醇之间存在显著相关性，而母亲与儿童之间的空腹胰岛素与所有血脂之间存在显著相关性，调整体重指数后这些相关性仍然显著。这些结果表明：（1）青少年空腹胰岛素与血脂和收缩压之间存在显著关系；（2）青少年与其父母之间这些因素存在显著关系。尽管在青春期体重似乎在这种关系中起重要作用，但除了通过体重介导的因素外，遗传和环境因素可能控制家庭内的胰岛素代谢。这些数据支持在生物发育早期进行研究以解决这些问题。
