Stricker R B, Goldberg B, Mills L B, Epstein W L
Department of Medicine, California Pacific Medical Center, San Francisco 94108, USA.
Res Virol. 1997 Sep-Oct;148(5):343-8. doi: 10.1016/s0923-2516(97)89130-3.
Quantitative measurement of human immunodeficiency virus (HIV) RNA is being used to assess the efficacy of various treatment modalities in HIV disease. Topical dinitrochlorobenzene (DNCB) therapy has been associated with improved clinical and immunologic parameters in HIV-infected patients. We have now examined the effect of topical DNCB treatment on plasma HIV RNA levels in a small prospective study. Eight HIV-infected subjects had T-cell counts and plasma viral load measured prior to initiation of DNCB therapy and 3-4 months after starting treatment. Six patients who refused DNCB therapy served as simultaneous controls. The mean CD4 and CD8 T-cell counts did not change significantly in either group over the study period. In contrast, plasma HIV RNA levels decreased one-half to greater than one log in each DNCB-treated subject, and the decrease in viral copies was statistically significant (p = 0.006). In the control group, plasma HIV RNA levels increased significantly over the course of the study (p = 0.037). We conclude that topical DNCB therapy has the ability to lower viral load in HIV-infected patients. The long-term effect on viral burden of this inexpensive, readily available therapeutic modality merits further investigation.
人类免疫缺陷病毒（HIV）RNA的定量检测正被用于评估HIV疾病中各种治疗方式的疗效。局部应用二硝基氯苯（DNCB）治疗与HIV感染患者临床和免疫指标的改善有关。我们现在通过一项小型前瞻性研究，检测了局部DNCB治疗对血浆HIV RNA水平的影响。8名HIV感染受试者在开始DNCB治疗前及治疗3 - 4个月后测量了T细胞计数和血浆病毒载量。6名拒绝DNCB治疗的患者作为同期对照。在研究期间，两组的平均CD4和CD8 T细胞计数均无显著变化。相比之下，每个接受DNCB治疗的受试者血浆HIV RNA水平下降了一半至超过一个对数，病毒拷贝数的下降具有统计学意义（p = 0.006）。在对照组中，血浆HIV RNA水平在研究过程中显著升高（p = 0.037）。我们得出结论，局部DNCB治疗能够降低HIV感染患者的病毒载量。这种廉价且易于获得的治疗方式对病毒负荷的长期影响值得进一步研究。
