Suzuki C, Ozaki I, Baba M, Onuma T, Suda T
Third Department of Internal Medcine, Hirosaki University School of Medicine.
Rinsho Shinkeigaku. 1997 Aug;37(8):697-700.
A 60-year-old woman, diagnosed as having a diabetic symmetrical proximal motor neuropathy, is presented. In March 1995, she was referred to us because of untreated diabetes mellitus since 1990. Insulin treatment during one month decreased her postprandial plasma glucose level from more than 400mg/dl to about 200mg/dl. Soon after the treatment, she noticed lower proximal limb weakness bilaterally. In several months, her weakness progressed as the fasting plasma glucose level was increased. Her muscle power gradually recovered when the plasma glucose level was normalized. We therefore suggest that metabolic changes related to hyperglycemia, rather than ischemic vascular changes, play an important role in the pathogenesis of a diabetic symmetrical proximal motor neuropathy.
本文报告了一名60岁女性，被诊断为糖尿病性对称性近端运动神经病。1995年3月，她因自1990年起未治疗的糖尿病而转诊至我院。经过一个月的胰岛素治疗，她的餐后血糖水平从超过400mg/dl降至约200mg/dl。治疗后不久，她双侧出现近端肢体无力。几个月后，随着空腹血糖水平升高，她的无力症状逐渐加重。当血糖水平恢复正常时，她的肌力逐渐恢复。因此，我们认为与高血糖相关的代谢变化而非缺血性血管变化在糖尿病性对称性近端运动神经病的发病机制中起重要作用。
