Kulalaeva Z I, Poltorak V A, Zaichkin E I, Tiurin V S, Silaev A B
Mikrobiologiia. 1976 Jan-Feb;45(1):133-6.
The vegetative mycelium of a submerged culture of Actinomyces flavus 12 was studied by complex electron microscopy (negative and positive contrasting, cryofractography) in the course of biosynthesis of flavofungin. The antibiotic is accumulated first in the cytoplasm as singular small granules which later grow larger. Accumulation of flavofungin is accompanied with destruction of the cytoplasm, nucleoid and other structures. Secretion of the antibiotic is supposed to be accomplished according to holocrine type.
在黄曲霉菌12深层培养的营养菌丝体合成黄曲菌素的过程中，通过复杂的电子显微镜技术（负染色和正染色、冷冻蚀刻）对其进行了研究。抗生素首先以单个小颗粒的形式积累在细胞质中，随后这些颗粒会逐渐变大。黄曲菌素的积累伴随着细胞质、类核和其他结构的破坏。据推测，抗生素的分泌是按照全质分泌类型进行的。
