Uchiyama Yusuke, Abe Toshi, Tanaka Norimitsu, Kojima Kazuyuki, Uchida Masafumi, Hirohata Masaru, Hayabuchi Naofumi
Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Radiat Med. 2006 Jun;24(5):321-6. doi: 10.1007/s11604-006-0030-5.
This study was performed to investigate the role of injection methods and conditions under a fixed dose of radiographic contrast medium (CM) in respect to promoting blood-brain barrier (BBB) disruption.
A total of 44 white rabbits (average body weight 2.7 +/- 0.4 kg) were used, and their carotid injection was performed with nonionic CM. The variables assessed for the carotid injections included the following: iodine content (300 or 150 mg I/ml), liquid temperature (37 degrees or 24 degrees C), and the injection time duration (1 or 30 s). The rabbits were divided into five groups. To evaluate BBB disruption, pre- and post-contrast-enhanced magnetic resonance (MR) studies were performed.
Abnormal enhancement of the brain parenchyma in MRI was noted in only one group, which consisted of high-iodine concentration CM injected at a low temperature over a short injection interval. Statistically significant increased values for the percentage of relative enhancement (RE%) were demonstrated (P < 0.05) in comparison with the saline-injected control group.
This result suggests variables that may need to be carefully considered to prevent BBB injury induced by nonionic CM for cerebral angiography, especially in the setting of a neurointerventional procedure.
本研究旨在探讨在固定剂量的放射造影剂（CM）下，注射方法和条件对促进血脑屏障（BBB）破坏的作用。
共使用44只白兔（平均体重2.7±0.4千克），用非离子型CM对其进行颈动脉注射。颈动脉注射评估的变量包括：碘含量（300或150毫克碘/毫升）、液体温度（37℃或24℃）以及注射持续时间（1或30秒）。将兔子分为五组。为评估血脑屏障破坏情况，在注射造影剂前后进行了磁共振（MR）研究。
仅在一组中观察到MRI脑实质异常强化，该组由在低温下短时间间隔注射高碘浓度CM组成。与注射生理盐水的对照组相比，相对强化百分比（RE%）有统计学意义的增加（P<0.05）。
该结果提示，在脑血管造影中，尤其是在神经介入手术中，为防止非离子型CM引起的血脑屏障损伤，可能需要仔细考虑一些变量。
