[The influence of the composition of the culture medium on the isoenzyme spectrum of Penicillium claviforme ribonucleases].

The dynamics of the activity of extracellular and intracellular RNases was studied with Penicillium claviforme growing (1) on the modified Ogata medium and (2) on the medium whose composition was optimized for biosynthesis of intracellular RNases. RNA-depolymerazing enzymes were compared when produced on the media 1 and 2. The isoenzyme composition of RNases was the same on both media though the ratio between the components and the time of their appearance were different. Changes in the activities of RNase, PME, and protease were similar during cultivation of Pen. claviforme on the media 1 and 2.