Romics I, Frang D, Bodrogi I
Department of Urology, National Institute of Oncology, Budapest, Hungary.
Int Urol Nephrol. 1997;29(4):449-55. doi: 10.1007/BF02551112.
Authors investigated PSA concentration and preoperative prostate volume in 113 histologically proved BPH and 31 prostatic cancer patients. PSA concentration was measured with the Hybritech kit, the prostate volume by ultrasound with the help of an ellipse and calculated by computer. There was no correlation between the age of patients and volume of the prostate, whereas a correlation was proved between marker concentration and prostate volume (p < 0.0001). The difference obtained by the correlation of the prostate volume and the PSA concentration ratio between the BPH and 31 tumorous patients (PSA density) was highly significant (0.143 vs. 0.699, p < 0.001). The use of PSAD further improves the diagnostic value of PSA.
作者对113例经组织学证实为良性前列腺增生（BPH）的患者和31例前列腺癌患者的前列腺特异性抗原（PSA）浓度及术前前列腺体积进行了研究。PSA浓度采用Hybritech试剂盒测定，前列腺体积借助椭圆超声测量并由计算机计算得出。患者年龄与前列腺体积之间无相关性，而标志物浓度与前列腺体积之间存在相关性（p < 0.0001）。BPH患者与31例肿瘤患者的前列腺体积与PSA浓度比值（PSA密度）相关性差异极为显著（0.143对0.699，p < 0.001）。使用前列腺特异性抗原密度（PSAD）进一步提高了PSA的诊断价值。
