Sangal R B, Sangal J M
Sleep Disorders Institute, Troy, Michigan, USA.
Sleep. 1997 Sep;20(9):702-4. doi: 10.1093/sleep/20.9.702.
This study evaluated the effects of 2-4 months of continuous positive airway pressure (CPAP) treatment on previously demonstrated P300 latency prolongations in obstructive sleep apnea (OSA). Subjects with severe OSA (respiratory disturbance index > 40/hour sleep) were administered polysomnograms, auditory and visual P300 testing using 31 scalp electrodes, and multiple sleep latency testing before and after treatment with CPAP for 2-4 months. Despite significant improvements in sleep and respiratory variables and the mean sleep latency, there were no significant P300 changes. Obstructive sleep apnea patients had prolonged visual P300 latency compared to normals, both before and after treatment. Prolongations in P300 latency that are resistant to the acute effects of CPAP may suggest that OSA causes physiological cortical changes that are unrelated to sleepiness and may be resistant to treatment.
本研究评估了持续气道正压通气（CPAP）治疗2至4个月对先前已证实的阻塞性睡眠呼吸暂停（OSA）患者P300潜伏期延长的影响。对重度OSA患者（呼吸紊乱指数>40次/小时睡眠）进行了多导睡眠图检查、使用31个头皮电极进行听觉和视觉P300测试，以及在CPAP治疗2至4个月前后进行多次睡眠潜伏期测试。尽管睡眠和呼吸变量以及平均睡眠潜伏期有显著改善，但P300没有显著变化。阻塞性睡眠呼吸暂停患者在治疗前后的视觉P300潜伏期均比正常人延长。对CPAP急性效应有抵抗的P300潜伏期延长可能表明，OSA会导致与嗜睡无关且可能对治疗有抵抗的生理性皮质变化。
