Ectopic production of beta-HCG by a maxillary squamous cell carcinoma.
作者信息
Scholl P D, Jurco S, Austin J R
机构信息
Austin Ear, Nose and Throat Associates, Texas 78705, USA.
出版信息
Head Neck. 1997 Dec;19(8):701-5. doi: 10.1002/(sici)1097-0347(199712)19:8<701::aid-hed8>3.0.co;2-9.
BACKGROUND
Paraneoplastic syndromes of the head and neck are rare. Hypercalcemia and leukocytosis have been described. The literature was reviewed, and a case of a squamous cell carcinoma of the maxilla producing beta human chorionic gonadotropin (beta-HCG) is presented.
METHODS
A 47-year-old white man with a T4N1M0 squamous cell carcinoma of the left maxilla was treated with a maxillectomy and neck dissection for an N1 positive neck. After completing his planned radiotherapy, he developed distant metastases, which included an axillary node that stained positive for human beta-HCG.
RESULTS
Retrospective review of the primary specimen showed beta-HCG positivity in an anaplastic component of the tumor along with vascular invasion.
CONCLUSIONS
The first case in the literature of a paraneoplastic syndrome with beta-HCG production in association with squamous cell carcinoma of the maxilla is presented. This case history fits the aggressive nature of beta HCG producing tumors elsewhere in the body.
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