Katz A J, Falchuk Z M, Shwachman H
Pediatrics. 1976 May;57(5):715-21.
Two patients with cystic fibrosis (CF) who subsequently developed celiac disease (CD) are described. Since organ culture of intestinal mucosa has been used to establish an in vitro model for the study of CD, we utilized this opportunity to determine whether duodenal mucosa obtained from each of these two patients and their immediate families differed in its organ culture behavior from mucosa obtained from patients with CD alone. Additionally, as specific HL-A types are associated with CD, we used HL-A typing to determine whether the two patients with CF-CD differed genetically from patients with CD alone. One of our patients was HL-A8, the most common type associated with CD; the other was HL-A12, as are many of the non-HL-A8 celiac patients. The response in organ culture of the mucosa of these two patients was the same as the response in organ culture of the mucosa from patients with CD alone. These and other data suggest that CD occurring in patients with CF is no different than CD occurring alone.
本文描述了两名患有囊性纤维化（CF）并随后患上乳糜泻（CD）的患者。由于肠道黏膜的器官培养已被用于建立研究CD的体外模型，我们利用这个机会来确定从这两名患者及其直系亲属获取的十二指肠黏膜在器官培养行为上是否与仅从CD患者获取的黏膜有所不同。此外，由于特定的HL - A类型与CD相关，我们使用HL - A分型来确定这两名CF - CD患者在基因上是否与仅患有CD的患者不同。我们的一名患者是HL - A8，这是与CD相关的最常见类型；另一名患者是HL - A12，许多非HL - A8的乳糜泻患者也是这种类型。这两名患者黏膜在器官培养中的反应与仅患有CD的患者黏膜在器官培养中的反应相同。这些以及其他数据表明，CF患者中出现的CD与单独出现的CD没有差异。
