Kao J H, Liu C J, Chen P J, Chen W, Hsiang S C, Lai M Y, Chen D S
Department of Internal Medicine, National Taiwan University College of Medicine, Taipei.
J Med Virol. 1997 Dec;53(4):348-53.
Although infection with GB virus-C/hepatitis G virus (GBV-C/HGV) by blood transfusion is well documented, little is known about the other routes of transmission. The prevalence of GBV-C/HGV infection in spouses of index patients and the related risk factors were studied. Hepatitis C virus (HCV) and GBV-C/HGV infections were studied in spouses of 100 patients with hepatitis C, of whom 12 were found to be also positive for GBV-C/HGV RNA. For couples both with GBV-C/ HGV viremia, nucleotide sequences of the divergent envelope region were analyzed by phylogenetic tree constructions. For HCV infection, anti-HCV was found in 14 (14%) of the 100 spouses. Five spouses (42%) of the 12 patients with dual infection of GBV-C/HGV and HCV had evidence of GBV-C/HGV infection, three had viral RNA, and two had antibodies to a recombinant HGV envelope protein E2. Nucleotide sequence comparison and phylogenetic tree analysis of the genome in the GBV-C/HGV infected couple revealed the isolates to be closely related. These results suggest that spouses of patients with GBV-C/HGV infection are at a higher risk of acquiring GBV-C/HGV as compared with HCV, and they should be educated to avoid GBV-C/HGV infection from their spouses, in case GBV-C/HGV is shown to be pathogenic.
尽管通过输血感染GB病毒C型/庚型肝炎病毒（GBV-C/HGV）已有充分记录，但对于其他传播途径却知之甚少。我们研究了索引患者配偶中GBV-C/HGV感染的患病率及相关危险因素。对100例丙型肝炎患者的配偶进行了丙型肝炎病毒（HCV）和GBV-C/HGV感染情况研究，其中12例被发现GBV-C/HGV RNA也呈阳性。对于夫妻双方均有GBV-C/HGV病毒血症的情况，通过构建系统发育树分析了其差异包膜区域的核苷酸序列。对于HCV感染，在100名配偶中有14名（14%）检测到抗-HCV。12例GBV-C/HGV和HCV双重感染患者的5名配偶（42%）有GBV-C/HGV感染证据，3名有病毒RNA，2名有针对重组HGV包膜蛋白E2的抗体。对GBV-C/HGV感染夫妻的基因组进行核苷酸序列比较和系统发育树分析，结果显示分离株密切相关。这些结果表明，与HCV相比，GBV-C/HGV感染患者的配偶感染GBV-C/HGV的风险更高，在GBV-C/HGV被证明具有致病性的情况下，应教育他们避免从配偶处感染GBV-C/HGV。
