van Luijtelaar E L
NICI, Department of Psychology, University of Nijmegen, The Netherlands.
Acta Neurobiol Exp (Wars). 1997;57(2):113-21. doi: 10.55782/ane-1997-1218.
Sleep spindles and spike-wave discharges are thought to originate from the same thalamic pacemaker. In the present work it is investigated whether sleep spindles and spike-wave discharges are also sensitive for the same drugs. Adult male WAG/Rij rats were chronically implanted with frontal and occipital EEG electrode pairs. Rats were intraperitoneally injected with clonidine (0.00625 mg/kg), phenobarbital (20 mg/kg), flunitrazepam (0.188 mg/kg). Frontal and occipital sleep spindles and mainly frontal spike-wave discharges were seen in the electroencephalogram. Phenobarbital and flunitrazepam reduced the number of spike-wave discharges and enhanced frontal sleep spindles, while clonidine facilitated spike-wave discharges and reduced frontal sleep spindles. The results of these three drugs indicate a reciprocal relationship between the number of frontal sleep spindles and the number of spike-wave discharges. Only clonidine facilitated occipital sleep spindles without an effect on spike-wave discharges. It can be concluded that frontal and occipital sleep spindles have a different pharmacological profile. Furthermore, the inverse relationship between frontal sleep spindles and spike-wave discharges may suggest that sleep spindles and spike-wave discharges are controlled by a single controlling system. However, in order to explain the clonidine data on occipital sleep spindles another factor must be incorporated in properties of the mechanism(s) involved in EEG oscillations.
睡眠纺锤波和尖波放电被认为起源于同一个丘脑起搏器。在本研究中，探讨了睡眠纺锤波和尖波放电对相同药物是否也敏感。成年雄性WAG/Rij大鼠被长期植入额叶和枕叶脑电图电极对。给大鼠腹腔注射可乐定（0.00625毫克/千克）、苯巴比妥（20毫克/千克）、氟硝西泮（0.188毫克/千克）。脑电图中可见额叶和枕叶睡眠纺锤波，主要是额叶尖波放电。苯巴比妥和氟硝西泮减少了尖波放电的数量并增强了额叶睡眠纺锤波，而可乐定促进了尖波放电并减少了额叶睡眠纺锤波。这三种药物的结果表明额叶睡眠纺锤波数量与尖波放电数量之间存在相互关系。只有可乐定促进了枕叶睡眠纺锤波，而对尖波放电没有影响。可以得出结论，额叶和枕叶睡眠纺锤波具有不同的药理学特征。此外，额叶睡眠纺锤波与尖波放电之间的反比关系可能表明睡眠纺锤波和尖波放电由单一控制系统控制。然而，为了解释可乐定对枕叶睡眠纺锤波的数据，必须将另一个因素纳入脑电图振荡所涉及机制的特性中。
