Qiao Y L, Taylor P R, Yao S X, Erozan Y S, Luo X C, Barrett M J, Yan Q Y, Giffen C A, Huang S Q, Maher M M, Forman M R, Tockman M S
Cancer Prevention Studies Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7326, USA.
Ann Epidemiol. 1997 Nov;7(8):533-41. doi: 10.1016/s1047-2797(97)00115-4.
To examine risk factors and establish a biologic specimen and data bank for the study of early markers of lung cancer.
We designed a dynamic cohort using an ongoing lung cancer screening program among radon- and arsenic-exposed tin miners in Yunnan China. Through the first four years of the study, 8,346 miners aged 40 years and older with over 10 years of occupational exposure have been enrolled, risk factors have been assessed, annual sputum and chest radiographs have been obtained, and numerous biologic specimens have been collected.
A total of 243 new lung cancer cases have been identified through 1995. Radon and arsenic exposures are the predominant risk factors, but lung cancer risk is also associated with chronic bronchitis and silicosis, as well as a number of exposure to tobacco smoke, including early age of first use, duration, and cumulative exposure. Tumor and sputum samples are being examined for early markers of lung cancer.
A cohort of occupationally-exposed tin miners with an extensive biologic specimen repository has been successfully established to simultaneously study the etiology and early detection of lung cancer.
研究肺癌早期标志物的危险因素并建立生物标本和数据库。
我们利用在中国云南对接触氡和砷的锡矿工人开展的一项正在进行的肺癌筛查项目设计了一个动态队列。在研究的头四年，已招募了8346名年龄在40岁及以上、有超过10年职业暴露史的矿工，评估了危险因素，每年获取痰液和胸部X光片，并收集了大量生物标本。
截至1995年共确诊了243例新的肺癌病例。氡和砷暴露是主要危险因素，但肺癌风险也与慢性支气管炎、矽肺以及多种烟草烟雾暴露有关，包括首次使用烟草的年龄、持续时间和累积暴露量。正在对肿瘤和痰液样本进行肺癌早期标志物检测。
已成功建立了一个职业接触锡矿工人队列，并拥有大量生物标本库，可同时研究肺癌的病因和早期检测。
