Duffaut M, Valla D
Service de Médecine Interne, Centre Hospitalier Régional de Toulouse.
Contracept Fertil Sex. 1997 Jul-Aug;25(7-8):534-7.
Medically assisted procreation poses a difficult problem when one or both partners of couple are infected with HCV. Epidemiologic and fundamental works show a low risk of HCV sexual transmission and no pregnancy complications or fetal abnormalities have been reported. However, the outcome of HCV infected children is unknown. These contrasting findings suggest that medically assisted procreation using sperm of spouse needs to be cautious. Before medically assisted procreation, testing of couples for HCV antibodies must be done and interferon therapy is required for patients with histological chronic active hepatitis and for HCV positive mothers or infected couples. In the absence of specific legislation or consensual recommendations, detailed informations must be given to the couples in order to obtain an informed consent.
当夫妻一方或双方感染丙型肝炎病毒（HCV）时，医学辅助生殖就会带来一个难题。流行病学和基础研究表明，HCV性传播风险较低，且未报告有妊娠并发症或胎儿异常情况。然而，感染HCV的儿童的预后尚不清楚。这些相互矛盾的研究结果表明，使用配偶精子进行医学辅助生殖需要谨慎。在进行医学辅助生殖之前，必须对夫妻进行HCV抗体检测，对于组织学上为慢性活动性肝炎的患者以及HCV阳性母亲或感染夫妻，需要进行干扰素治疗。在缺乏具体立法或共识性建议的情况下，必须向夫妻提供详细信息，以便获得知情同意。
