Ahrné S, Franklin A
Laboratoriet för livsmedels-hygien, Lunds universitet.
Lakartidningen. 1997 Oct 1;94(40):3493-5.
In the modern world, as refrigerated storage has replaced lactic acid fermentation methods of food preservation, we no longer ingest large quantities of live lactobacilli with our food, but relatively large numbers of potentially pathogenic Gram-negative bacteria instead. In the brave new world, antibiotics are used as growth-promoting additives in animal feed in every country but Sweden. The antibiotics used in Europe at low dosages, and exempt from prescription requirements, include macrolides, streptogramins and nitro-imidazoles. There is reason to believe that avoparcin, recently banned in Europe as an antibiotic animal feed additive, has contributed to the occurrence of vancomycin-resistant enterococci in humans. Animal foodstuffs production in Europe and the USA is so intensive that it provides very favourable conditions for the spread of bacteria. Pig, cattle and poultry breeding in Europe are beset by formidable difficulties in the form of Salmonella infections, which constitute not only a hygiene but also a clinical problem. Sweden, the bravest of brave new worlds, faces an increase in the influx of domestic animals and foodstuffs from other countries, and in general less restrictive regulations concerning food production and animal husbandry, but reduced powers of control. Thus, we may expect problems both with pathogens (traditional ones such as Salmonella, and potential ones such as food-spoilage Gram-negative bacteria), and with antibiotic-resistant bacteria in our food-stuffs, to become greater.
在现代社会,由于冷藏储存已取代了乳酸发酵的食品保存方法,我们不再通过食物摄入大量活的乳酸菌,而是摄入了相对大量的潜在致病革兰氏阴性菌。在这个全新的世界里,除了瑞典,每个国家都将抗生素用作动物饲料中的生长促进添加剂。在欧洲,低剂量使用且无需处方的抗生素包括大环内酯类、链阳菌素类和硝基咪唑类。有理由相信,最近在欧洲被禁止作为抗生素动物饲料添加剂的阿伏霉素,促成了人类中耐万古霉素肠球菌的出现。欧洲和美国的动物食品生产非常密集,为细菌传播提供了非常有利的条件。欧洲的猪、牛和家禽养殖面临着沙门氏菌感染这一巨大难题,沙门氏菌感染不仅构成卫生问题,也构成临床问题。瑞典,这个全新世界中最为大胆的国家,面临着来自其他国家的家畜和食品流入增加的情况,总体上食品生产和畜牧业的监管限制较少,但控制能力却有所下降。因此,我们可能预计食品中的病原体(如传统的沙门氏菌以及潜在的如导致食物变质的革兰氏阴性菌)和抗生素耐药菌问题会变得更加严重。