Kimak E, Solski J, Janicka L, Duma D, Zagojska M
Department of Clinical Analytics, Medical School of Lublin, Poland.
Int Urol Nephrol. 1997;29(5):597-601. doi: 10.1007/BF02552207.
The clinical picture in chronic renal failure (CRF) shows great variability depending on age, sex, aetiology of disease, grades of renal injury and type of treatment. Significant increases of triglycerides (TG), low-density lipoprotein cholesterol (LDL-chol) and and apo B concentrations, significant decreases of high-density lipoprotein cholesterol (HDL-chol) levels and apo A and apo AI concentrations, and no significant changes in total cholesterol (TC) have been shown in CRF patients. Significant increases of TC/HDL-chol, LDL-chol/HDL-chol, apo B/apo AI and apo B/LDL-chol ratios were also demonstrated. That indicates a high risk of atherosclerosis even when total cholesterol levels are in the normal range. There were highly significant and positive correlations between TC/HDL-chol and LDL-chol/HDL-chol ratios, apo B and LDL-chol concentrations as well as between the apo B/apo AI and LDL-chol/HDL-chol ratios.
慢性肾衰竭（CRF）的临床表现因年龄、性别、疾病病因、肾损伤程度及治疗类型的不同而有很大差异。CRF患者甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-chol）及载脂蛋白B浓度显著升高，高密度脂蛋白胆固醇（HDL-chol）水平、载脂蛋白A及载脂蛋白AI浓度显著降低，总胆固醇（TC）无显著变化。TC/HDL-chol、LDL-chol/HDL-chol、载脂蛋白B/载脂蛋白AI及载脂蛋白B/LDL-chol比值也显著升高。这表明即使总胆固醇水平在正常范围内，动脉粥样硬化风险也很高。TC/HDL-chol与LDL-chol/HDL-chol比值、载脂蛋白B与LDL-chol浓度之间以及载脂蛋白B/载脂蛋白AI与LDL-chol/HDL-chol比值之间存在高度显著的正相关。
