MMWR Morb Mortal Wkly Rep. 1997 Dec 19;46(50):1204-7.
A strain of influenza virus that previously was known to infect only birds has been associated with infection and illness in humans in Hong Kong. The first known human case of influenza type A(H5N1) occurred in a 3-year-old child who died from respiratory failure in May 1997. In Hong Kong, the virus initially was identified as influenza type A, but the subtype could not be determined using standard reagents. By August, CDC; the National Influenza Center, Rotterdam, the Netherlands; and the National Institute for Medical Research, London, United Kingdom, had independently identified the virus as influenza A(H5N1). An investigation conducted during August-September by the Hong Kong Department of Health and CDC excluded the possibility of laboratory contamination. Since this initial case was identified, six additional persons in Hong Kong have been confirmed to have influenza A(H5N1) infection, and two possible cases have been identified. This report summarizes the nine cases identified thus far and describes preliminary findings from the ongoing investigation, which indicate that multiple influenza A(H5N1) infections have occurred and that both the source and mode of transmission are uncertain at this time.
一种以前仅已知可感染禽类的流感病毒株已在香港导致人类感染和发病。首例已知的甲型（H5N1）流感人类病例发生在一名3岁儿童身上，该儿童于1997年5月死于呼吸衰竭。在香港，该病毒最初被鉴定为甲型流感，但使用标准试剂无法确定其亚型。到8月时，美国疾病控制与预防中心（CDC）、荷兰鹿特丹国家流感中心以及英国伦敦国家医学研究所已独立将该病毒鉴定为甲型（H5N1）流感。香港卫生署和美国疾病控制与预防中心在8月至9月期间进行的一项调查排除了实验室污染的可能性。自首例病例被确认以来，香港又有另外6人被确诊感染甲型（H5N1）流感，还有2例疑似病例被发现。本报告总结了迄今为止确认的9例病例，并描述了正在进行的调查的初步结果，这些结果表明已发生多起甲型（H5N1）流感感染，目前传染源和传播方式均不确定。
